与氯己定和次氯酸钠相比，买菜做饭13825404095去污剂HybenX®的体外抗菌活性对常见细菌和酵母菌病原体。
Antibiotics
(
IF
4.3
)
Pub Date : 2019-10-17
, DOI:
10.3390/antibiotics8040188
Alberto Antonelli
1
,
Luca Giovannini
1
,
Ilaria Baccani
1
,
Valentina Giuliani
1,
2
,
Riccardo Pace
2
,
Gian Maria Rossolini
1,
3
Affiliation
Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.
Odontostomatology-Endodontic Unit, Careggi University Hospital, 50134 Florence, Italy.
Clinical Microbiology and Virology Unit, Careggi University Hospital, 50134 Florence, Italy.
由耐药细菌和真菌病原体介导的感染的近期增加强调了对新型抗菌化合物的迫切需求。在这项研究中，与常用的次氯酸钠和洗必泰相比，新型干燥剂HybenX®对一组代表最常见人类病原体的细菌和酵母菌株的抗菌活性（抑制性和杀灭性）进行了评估。通过肉汤微量稀释测定法评估三种不同抗微生物剂的最小抑菌，杀菌和杀真菌浓度（分别为MIC，MBC和MFC），然后对合适的稀释液进行亚培养。HybenX®对代表葡萄球菌，肠球菌，肠杆菌，革兰氏阴性非发酵剂和酵母菌的26种参考菌株具有活性，尽管其浓度高于次氯酸钠和洗必泰。细菌的HybenX®MIC为0.39％（MBC在0.39％至0.78％之间），酵母为0.1-0.78％（MFC在0.78％至1.6％之间）。HybenX®在低浓度下对几种细菌和酵母病原体表现出有效的抑制和杀灭活性。这些发现表明，作为次氯酸钠和洗必泰的替代品，HybenX®可能对治疗牙周和牙髓感染以及其他粘膜和皮肤的细菌和真菌感染具有重要意义。HybenX®在低浓度下对几种细菌和酵母病原体表现出有效的抑制和杀灭活性。这些发现表明，作为次氯酸钠和洗必泰的替代品，HybenX®可能对治疗牙周和牙髓感染以及其他粘膜和皮肤的细菌和真菌感染具有重要意义。HybenX®在低浓度下对几种细菌和酵母病原体表现出有效的抑制和杀灭活性。这些发现表明，作为次氯酸钠和洗必泰的替代品，HybenX®可能对治疗牙周和牙髓感染以及其他粘膜和皮肤的细菌和真菌感染具有重要意义。
In Vitro Antimicrobial Activity of the Decontaminant HybenX® Compared to Chlorhexidine and Sodium Hypochlorite against Common Bacterial and Yeast Pathogens.
The recent increase in infections mediated by drug-resistant bacterial and fungal pathogens underlines the urgent need for novel antimicrobial compounds. In this study, the antimicrobial activity (inhibitory and cidal) of HybenX®, a novel dessicating agent, in comparison with commonly used sodium hypochlorite and chlorhexidine, against a collection of bacterial and yeast strains representative of the most common human pathogenic species was evaluated. The minimal inhibitory, bactericidal, and fungicidal concentrations (MIC, MBC, and MFC, respectively) of the three different antimicrobial agents were evaluated by broth microdilution assays, followed by subculturing of suitable dilutions. HybenX® was active against 26 reference strains representative of staphylococci, enterococci, Enterobacterales, Gram-negative nonfermenters, and yeasts, although at higher concentrations than sodium hypochlorite and chlorhexidine. HybenX® MICs were 0.39% for bacteria (with MBCs ranging between 0.39% and 0.78%), and 0.1-0.78% for yeasts (with MFCs ranging between 0.78% and 1.6%). HybenX® exhibited potent inhibitory and cidal activity at low concentrations against several bacterial and yeast pathogens. These findings suggest that HybenX® could be of interest for the treatment of parodontal and endodontic infections and also for bacterial and fungal infections of other mucous membranes and skin as an alternative to sodium hypochlorite and chlorhexidine.
